Semaglutide vs Tirzepatide: A Head-to-Head Comparison
Both semaglutide and tirzepatide are powerful weight loss medications, but they work differently. Here's everything you need to know to make an informed choice.
How They Work
Semaglutide is a GLP-1 receptor agonist that mimics one gut hormone. Tirzepatide is a dual GIP/GLP-1 receptor agonist that mimics two gut hormones, potentially providing enhanced metabolic effects.
Weight Loss Results
In the SURMOUNT trials, tirzepatide achieved up to 22.5% body weight reduction at the highest dose. Semaglutide achieves 15-20% in the STEP trials. Both represent dramatic improvements over older weight loss medications.
Side Effects Comparison
Both medications share similar gastrointestinal side effects including nausea, diarrhea, and constipation. Side effect rates are comparable between the two medications and typically improve with time.
Cost and Availability
Brand-name versions of both cost $1,000-1,600 per month. However, compounded semaglutide is more widely available and affordable, making it the more accessible option for many patients. Check our cost guide for savings options.
Which Should You Choose?
Both are excellent choices. Semaglutide has a longer track record, more insurance coverage, and better availability through compounding pharmacies. Tirzepatide may produce slightly more weight loss but at higher cost. Your provider can help you decide based on your specific health needs.