How to Inject Semaglutide: Step-by-Step Guide

Injecting semaglutide at home is simple and virtually painless. Follow this step-by-step guide for safe, effective self-injection.

Before You Begin

• Wash your hands thoroughly with soap and water
• Check the medication — it should be clear and colorless
• Let refrigerated medication reach room temperature (15-30 minutes)
• Gather supplies: pen/syringe, alcohol swab, sharps container

Step-by-Step Injection Process

1. Choose your site: Select an injection site — abdomen, thigh, or upper arm
2. Clean the area: Swab the injection site with an alcohol pad and let it dry
3. Prepare the dose: Dial your prescribed dose on the pen or draw up the correct amount
4. Pinch the skin: Gently pinch a fold of skin at the injection site
5. Insert the needle: Push the needle straight in at a 90-degree angle
6. Inject slowly: Press the plunger steadily and hold for 5-10 seconds
7. Remove: Pull the needle straight out and release the skin fold
8. Dispose safely: Place the needle in a sharps container immediately

After Your Injection

Do not rub the injection site. A small amount of redness or bruising is normal. If you see a drop of blood, apply gentle pressure with a clean cotton ball. Store your pen properly — unused pens in the refrigerator, in-use pens at room temperature for up to 56 days.

Tips for a Comfortable Experience

• Rotate injection sites each week to prevent irritation
• Inject at the same time on the same day each week
• Relax the muscle at the injection site — tension increases discomfort
• If nervous, apply an ice cube to the area for 30 seconds before injecting